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Impact of acute fonofos exposure on skeletal muscle of zebrafish: Histopathological and biometric analyses

Sezgi Arman and Sema İşisağ Üçüncü

The present work investigated histological changes in skeletal muscles of zebrafish (Danio rerio) caused by fonofos, an organophosphate insecticide. Fonofos-induced fibrosis, intramyofibrillar vacuoles, disintegrated myofibrils, splitting of myofibers, atrophic and disappeared fibers, histoarchitectural loss, necrosis and progressive decrement in glycogen content were noted. Muscle fiber diameter measurements showed that the fiber diameters of all fonofos exposed groups were decreased in a concentration-dependent manner. These results suggested that fonofos caused significant myoarchitectural impairments in non-target freshwater zebrafish.

Ann. Limnol. - Int. J. Lim., 57 (2021) 25
Published online: 25 November 2021
DOI: 10.1051/limn/2021023

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